I don't agree with disrespecting people. However, in the concept of comedy it is just a joke. For instance, I used to sleep in a car. If someone made a joke about that, I could laugh it off.
True but at the same time not everyone has your sense of humor. It might be a joke but there are others who might be sensitive about things like this and take it the wrong way. And there are also cases where you might not be emotionally stable to take such jokes.
Everyone has to understand the general disposition of people before they go ahead to crack jokes using the person. It can even make some people Very depressed.